A History of Industrial Chemistry by F. Sherwood. Taylor

By F. Sherwood. Taylor

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2 Properties of Chemicals Tested for Carcinogenicity . . . . . . . . . 3 Species and Strains of Test Animals . . . . . . . . . . . . . . . . . 4 Route of Administration of Test Chemicals . . . . . . . . . . . . . 5 Dose Selection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Inception and Duration of Exposure . . . . . . . . . . . . . . . . . 7 Numbers of Animals, Methods of Randomization, and Statistics of the Carcinogenic Response .

The strain usually used is one with little or no incidence of spontaneous tumors and a high and specific susceptibility to many carcinogens. Certain strains will produce a biological response to a test carcinogen and others may not. For example, a single administration of 7,12-dimethylbenz[a]anthracene (DMBA) induces mammary tumors in Sprague-Dawley rats but not in Long-Evans rats [23]. Similarly, aflatoxin B1 induces a high incidence of liver tumors in both Wistar and Fisher rats and a high incidence of kidney tumors in Wistar rats but not in Fisher rats [24].

Dusts Wood Leather C. Physical agents 1. Nonionizing radiation Ultraviolet rays 2. C. 7 Federally Regulated Workplace Carcinogens under Occupational Safety and Health Act [16] Name of carcinogen 1. Asbestos 2. 13 Carcinogens 4-Nitrobiphenyl α-Naphthylamine Methyl chloromethylether 3,3 -Dichlorobenzidine bis-Chloromethyl ether β-Naphthylamine Benzidine 4-Aminodiphenyl Ethyleneimine β-Propiolactone 2-Acetylaminofluorene 4-Dimethylaminoazobenzene N-Nitrosodimethylamine 3. Vinyl chloride 4. Inorganic arsenic 5.

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