By Silvio Garattini
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Additional resources for Advances in Pharmacology and Chemotherapy Volume 17
17 Information Services of the International Cancer Research Data Bank (ICRDB) Program in Cancer Chemotherapy and Pharmacology JOHN H. SCHNEIDER International Cancer Research Data Bank Program National Cancer Institute Bethesda, Maryland . . . . . . . . . . . . . . . . . . A. Abstracts of Published Literature . . . . . B. Descriptionsof Current Cancer Research Projects . . C. Outlines of Clinical Cancer Protocols . . . . ICRDB Data Bases for Cancer Researchers . . .
37 41 41 45 50 50 57 66 68 74 76 80 80 83 86 87 87 87 90 91 91 92 92 92 93 94 . 1 Introduction Dihydrofolate reductase (DHFR) (tetrahydrofolate N A D P oxidoreductase. 5. 3) catalyzes the NADPH-dependent reduction of 7. 8. 7. tetrahydrofolate (THF) (see Fig . 1): DHF + NADPH + H+ THF + NADP (1) THF is a coenzyme in a number of 1-carbon transfer reactions (Rader and 37 Copyright 0 1980 by Academic Press.
Again, in a situation where only small quantities of experimental compounds were available, we found the cell culture system very useful for cross-resistance studies in a group of ionophores. 20 JOHN F. RYLEY VI. Polnt and Type of Action Studies It is interesting to have information on the point in the life cycle at which a compound acts and whether this activity is coccidistatic or coccidicidal. Such information is useful when considering the likely effects of withdrawal or interruption of medication-intentional or otherwise-and the likely effect of drugs prophylaxis on the development of flock immunity.