Advances in Pharmacology and Chemotherapy Volume 17 by Silvio Garattini

By Silvio Garattini

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17 Information Services of the International Cancer Research Data Bank (ICRDB) Program in Cancer Chemotherapy and Pharmacology JOHN H. SCHNEIDER International Cancer Research Data Bank Program National Cancer Institute Bethesda, Maryland . . . . . . . . . . . . . . . . . . A. Abstracts of Published Literature . . . . . B. Descriptionsof Current Cancer Research Projects . . C. Outlines of Clinical Cancer Protocols . . . . ICRDB Data Bases for Cancer Researchers . . .

37 41 41 45 50 50 57 66 68 74 76 80 80 83 86 87 87 87 90 91 91 92 92 92 93 94 . 1 Introduction Dihydrofolate reductase (DHFR) (tetrahydrofolate N A D P oxidoreductase. 5. 3) catalyzes the NADPH-dependent reduction of 7. 8. 7. tetrahydrofolate (THF) (see Fig . 1): DHF + NADPH + H+ THF + NADP (1) THF is a coenzyme in a number of 1-carbon transfer reactions (Rader and 37 Copyright 0 1980 by Academic Press.

Again, in a situation where only small quantities of experimental compounds were available, we found the cell culture system very useful for cross-resistance studies in a group of ionophores. 20 JOHN F. RYLEY VI. Polnt and Type of Action Studies It is interesting to have information on the point in the life cycle at which a compound acts and whether this activity is coccidistatic or coccidicidal. Such information is useful when considering the likely effects of withdrawal or interruption of medication-intentional or otherwise-and the likely effect of drugs prophylaxis on the development of flock immunity.

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