Advances in Pharmacology and Chemotherapy Volume 7 by Silvio Garattini

By Silvio Garattini

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1 <4 Normal ? Truncate Y p + e3. 3 ? 8 Normal 7-11 Normal 14 ? West Bengal Markham Negro Welsh-Scottish ? 6 ? 4 Normal 162-222 ? Truncate ? Mildly biphasic Mildly biphasic ? Mildly biphesio Truncate Very biphasic Uncommon variants, with congenital nonspherocytic hemolytic disease a Slightly Slightly Normal increased increased 224 ? 14 Greatly reduced Reduced Greatly reduced ? Truncate Narrow peak ? Narrow peak From Kirkman (1968). w l 38 ELLIOT 9. VESELL increased frailty of G-6-PD-deficient erythrocytes.

Alternatively, both drugs may be degraded by similar enzymatic steps. Whatever the explanation, the existence of such a correlation raises the possibility that \\ithin an individual the rates of metabolism of other drugs may also be correlated. Recent work by Hammer et al. (1969)demonstrates correlation of the rates of 14 ELLIOT S. VESELL metabolism of desmethylimipramine, nortriptyline, and oxyphenylbutazone. The close correlation between the rates of metabolism of these three drugs is strikingly illustrated in Fig.

Residual enzymatic ootivity and antigenic determinants occurred in three subjects who revealed a single band on the starch gel a t the C-4position when their sera were concentrated 6-fold. I n the remaining two cases, results similar to those of Hodgkin et al. were obtained. C-utsche, Scott, and Wright (1967)reported a high incidence of the silent mutation in a population of southern Eskimos. Nineteen cases in 11 Eskimo families were ascertained as a result of apnea in 2 Eskimo children after a single low dose of succinylcholine.

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