By Tim D. Spector, Harold Snieder, Alex J. MacGregor
Dual and relatives information have generally been used to quantify the genetic and environmental contribution to sickness. in the course of the software of latest analytical methods, those designs may also offer strong versions within which the quest for particular genes underlying non-Mendelian ailments might be optimised. This booklet discusses the state of the art in dual and sib-pairs research of complicated illnesses either from the point of view of epidemiology (study layout, topic choice, sampling thoughts) and biostatistics (path research, survival research, linkage research, organization studies). Novel methods are mentioned during which twins and sib-pairs can be utilized to fulfill the problem of opting for the positioning and serve as of genes underlying advanced characteristics. This publication will entice quite a lot of biomedical scientists attracted to the genetic foundation of disorder, epidemiologists, molecular biologists, human geneticists and scholars.
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Extra info for Advances in Twin and Sib-pair Analysis
Page 23 3 Sample Selection and Outcome Definition in Twin Studies: Experiences From the Finnish Twin Cohort Study Jaakko Kaprio Pia K. Verkasalo Markku Koskenvuo Page 24 ABSTRACT The purpose of this chapter is to review some of the issues related to study design that investigators should consider. The chapter is not exhaustive but draws on our experiences in conducting the Finnish twin cohort studies. The study hypothesis should guide sample selection and outcome definition, so that the study has adequate statistical power and makes efficient use of the data that is collected.
Some ply these treacherous waters without trepidation; however, many are daunted by the seemingly unfathomable depths and by the sheer distance of the far horizon. The idea behind the First International Workshop on the Genetic Epidemiology of Complex Traits using Twins and Sib-pairs at St Catharine's College, Cambridge in 1998, was to help fellow voyagers embark but be aware of the dangers. By bringing together a disparate crew of epidemiologists, clinicians, statisticians and geneticists for two intense days in the austere but historic atmosphere of the Mill Lane lecture theatres we hoped to chart a common course.
We are also grateful to our main meeting sponsors, Gemini Research Ltd of Cambridge, UK, with additional thanks to SKB and Zeneca PLC for their support. S. S. J. MacG JULY 1999 Page 1 1 The History of Twin and Sibling-Pair Studies Tim D. Spector Page 2 ABSTRACT This chapter briefly discusses the origins of the classical twin study and what is today known as the sib pair method. Although Galton is rightly known as the father of behavioural and quantitative genetics and recognised that the study of twins could shed light on the effects of environment, it was unclear whether he suspected there were two biological types of twin.